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Image Search Results
Journal: Pharmaceuticals
Article Title: Acquired Drug Resistance Enhances Imidazoquinoline Efflux by P-Glycoprotein
doi: 10.3390/ph14121292
Figure Lengend Snippet: ( A ) MDR cancer cells were derived from parent cancer cell lines by incrementally increasing the Dox concentration in growth media. ( I ) TRAMP-C2 (TC2) prostate parent cancer cell line. ( II ) B16-F10 (B16) melanoma parent cancer cell line. ( III ) 4T1-Luc2 (4T1) breast parent cancer cell line. ( IV ) TC2-MDR cancer cell line. ( V ) B16-MDR cancer cell line. ( VI ) 4T1-MDR cancer cell line. Scale: 200 µm ( B ) Western blot shows the increased expression of P-gp in MDR cancer cells compared to parent cancer cell lines. ( C ) TC2-Parent, TC2-MDR, B16-Parent, and B16-MDR stained with Anti-P-gp-Alexa Fluor 488 antibody conjugate reveals the increased expression of P-gp in MDR-derived cancer cell lines, as well as membrane localization of P-gp.
Article Snippet: As per manufacturer instructions, the
Techniques: Derivative Assay, Concentration Assay, Western Blot, Expressing, Staining, Membrane